MEPSA PROGRAMME

 

WEDNESDAY 26 NOVEMBER 2003

 

8.30-9.15 Registration

 

9.15-9.30 Opening Comments

 

9.30-10.30 Wilhelm Lecture. Professor Bruce Armstrong. Your personalised prevention prescription, Sir - circa 2010. School of Population Health and Health Services Research, The University of Sydney

 

10.30-11.00 Morning Tea

 

11.00-11.20 The hepatic transcriptome in hepatitis C virus (HCV) associated cirrhosis with hepatocellular cancer (HCC). Huang, XX), Gorrell MD, Williams RBH, Seth, D, Shackel, NA, McCaughan GW. AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital and Discipline of Medicine, University of Sydney and Centenary Institute, Sydney. x.huang@centenary.usyd.edu.au

 

11.20-11.40 Dairy foods, vitamin D and colon cancer prevention. McIntosh GH. CSIRO Health Sciences and Nutrition, PO Box 10041, Adelaide, SA 5000. Graeme.McIntosh@csiro.au

 

11.40-12.00 TGF-b1 Influences the Number and Function of Skin Tumour-Infiltrating Immune Cells. Matthew Knox, Gary Halliday and Scott Byrne. Department of Medicine (Dermatology), Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, University of Sydney at Royal Prince Alfred Hospital, NSW, 2006. matty knox@yahoo.com.au

 

12.00-12.20. Rate Limiting Steps in Base Excision Repair After Exposure to Arsenic. Peter Sykora and ET Snow. Faculty of Science and Technology, Deakin University. esnow@deakin.edu.au

 

12.20-12.40. Evaluation of the Safety, Tolerability and Efficacy of Melanotan in Healthy Caucasians TKT Ooi and RStC Barnetson  Department of Medicine (Dermatology), Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, University of Sydney at Royal Prince Alfred Hospital, NSW, 2006. terryo@med.usyd.edu.au

 

12.40-1.50 Lunch

 

1.50-2.10. Probiotic Bacteria, When Combined with the Prebiotic Resistant Starch, can Facilitate Apoptosis of DNA-Damaged Cells. RK Le Leu, IL Brown*, Y Hu and GP Young.   Centre for Digestive Health, Flinders Medical Centre, South Australia, 5042, *National Starch & Chemical Company, Bridgewater, New Jersey, USA. Richard.LeLeu@flinders.edu.au

 

2.10-2.30 Defective Colonic Acute Apoptotic Response to Carcinogen in p53^+/- Mice is Associated with Increased Susceptibility to Oncogenesis. ­Y Hu, RK le Leu and GP Young. Centre for Digestive Health, Flinders Medical Centre and Flinders University, South Australia, 5042. ying.hu@flinders.edu.au

 

2.30-2.50. Caspase 3 Mediates Sodium Butyrate Induced Apoptosis in HaCat Keratinocytes. Ilse S Daehn1, Antiopi Varelias¹, Timothy E Rayner^1,2.1Wound Healing and Injury Research Centre, University of Adelaide Department of Surgery, The Queen Elizabeth Hospital, Woodville, ²Child Health Research Institute, Women’s and Children’s Hospital, North Adelaide, SA. daeh0002@flinders.student.edu.au

 

2.50-3.10 Potent Iron Chelators Affect the Expression of Multiple Molecules Involved in Cell Cycle Progression, Metastasis, DNA Excision and Apoptosis Effie Nurtjahha-Tjiendraputra, Nghia TV Le, Des R Richardson Iron Metabolism and Chelation Program, Children’s Cancer Institute Australia for Medical Research, PO Box 81, High Street, Randwick, Sydney, NSW, 2031, Australia

 

3.10-3.30 Mechanism of Action of Topical Imiquimod for the Treatment of Actinic Keratoses TKT Ooi, LQ Zhuang, GM Halliday and RStC Barnetson. Department of Medicine (Dermatology), Melanoma and Skin Cancer Research Institute, University of Sydney at Royal Prince Alfred Hospital, NSW, 2006. terryo@med.usyd.edu.au

 

3.30-4.00 Afternoon tea

 

4.00-4.20 Carnosine Augments Collagen Synthesis Stimulated by Whey-Derived Growth Factors in Human Skin Fibroblasts. Antiopi Varelias¹, Geoffrey W Grigg², Anthony R Dyer³, and Timothy E Rayner ^{1,3 1}Wound Healing and Injury Research Centre, Univeristy of Adelaide Department of Surgery, The Queen Elizabeth Hospital, Woodville, SA, 5011, ²Beta Peptide Foundation Pty Ltd, Balmain, NSW, 2041, ³TGR BioSciences Pty Ltd, Thebarton, SA, 5031. antopi.varelias@nwahs.sa.gov.au

 

4.20-4.40. Skin Fibroblast Function is Compromised by T Cells. Guldana Ruzehaji¹, Ilse S Daehn¹, Antiopi Varelias¹ and Timothy E Rayner ^{1,2 1}Wound Healing and Injury Research Centre, University of Adelaide Department of Surgery, The Queen Elizabeth Hospital, Woodville, ²Child Health Research Institute, Women’s and Children’s Hospital, North Adelaide, SA. tim.rayner@adelaide.edu.au

 

4.40-5.00 Strong Adduct-Trapping in Liver Proteins Accompanies Protection Against Allyl Alcohol Hepatoxicity by Hydralazine in Mice LM Kaminskas, PC Burcham, SM Pyke Molecular Toxicology Group, Clinical and Experimental Pharmacology, University of Adelaide, SA, 5005 lisa.kaminskas@adelaide.edu.au

 

5.00-5.20 Hydralazine Dose Dependently Protects Against the Side Effects of Cyclophosphamide in Male Swiss Mice DB Ascher and PC Burcham Molecular Toxicology Group, Clinical and Experimental Pharmacology, University of Adelaide, SA, 5005 david.ascher@adelaide.edu.au

 

 

5.20-?   Welcome drinks

 

 

THURSDAY 27 NOVEMBER 2003

 

9.30 – 10.30. Burnet Lecture. Honnavara.N. Ananthaswamy. Role of p53 in UV-induced apoptosis and carcinogenesis. Ashbel Smith Professor and Deputy Chairman Department of Immunology, The University of Texas, MD Anderson Cancer Center, Houston, Texas. hanantha@mdanderson.org

 

10.30-11.00 Morning tea

 

11.00-11.20. UV-Induced Regulatory B Cells Suppress Immune Activation by Dendritic Cells Byrne SN, Spinks N and Halliday GM Department of Medicine (Dermatology), Melanoma and Skin Cancer Research Institute, Sydney  Cancer Centre, Royal Prince Alfred Hospital at the University of Sydney, 2006. scottb@med.usyd.edu.au

 

11.20-11.40 Protection of murine NK cell activity and contact hypersensitivity responses from solar simulated UV radiation by the flavonoid luteolin Quinn C, Reeve, VE. Faculty of Veterinary Science, University of Sydney, NSW, Australia, 2006 cqui1070@mail.usyd.edu.au

 

11.40-12.00 UV and CIS-Urocanic Acid Enhances Mycobacterium Ulcerans Infection in a CRL:IAF(HA)-HRBR Hairless Guinea Pig Model of Buruli Ulcer Disease Cope RB¹, Stang B¹, Valentine BA¹, Small PLC², Bermudez LE ^{1,3  1}College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA, ²Department of Microbiology, University of Tennessee, ³Department of Microbiology, Oregon State University rhian.cope@oregonstate.edu

 

12.00-12.20 Action Spectrum for Ultraviolet Radiation-Induced Suppression of Contact Hypersensitivity Responses to a Recall Antigen in Humans  Phan TA, Halliday GM, Barnetson RStC and Damian DL.  Dermatology, Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, University of Sydney at Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050, Australia  tai@med.usyd.edu.au

 

12.20 – 12.40 Immunomodulating action of UVA (320-400 nm) radiation can be mimicked by carbon monoxide-releasing molecule (CO-RM). Allanson M and Reeve VE. Faculty of Veterinary Science, University of Sydney, NSW, Australia m.allanson@vetp.usyd.edu.au

 

12.40-1.50 Lunch

 

1.50-2.10 UVB, but not UVA or Visible Light, Augments the Formation of Melanocytic Naevi in a Guinea Pig Model for Human Naevi  Menzies SW, Greenoak GE, Abeywardana CM, Crotty KA, O’Neill ME  Sydney Melanoma Diagnostic Centre, Sydney cancer Institute, Royal Prince Alfred Hospital and Faculty of Medicine, University of Sydney, NSW 2006 [S.W.M, C.M.A.], Skin and Cancer Foundation, Darlinghurst, NSW 2010 [K.A.C.], Australian Photobiology Testing Facility [G.E.G.], Faculty of Agriculture, Food and Natural Resources, University of Sydney, NSW 2006 [M.E.O.]

 

2.10- 2.30 Immune damage by ssUV is attenuated by endogenous and exogenous melatonin in mice. Lachireddy K and Reeve V. Faculty of Veterinary Science, University of Sydney, NSW, Australia. lkishen@vetp.usyd.edu.au

 

2.30-2.50 Topical Melantonin: Immune-Protection in Humans?  Howes RA, Halliday GM, Barnetson RStC, Damian DL  Dermatology Research laboratories, Melanoma and Skin Cancer Research Institute at Royal Prince Alfred Hospital, University of Sydney, NSW 2006, Australia  renaeh@med.usyd.edu.au

 

 

2.50-3.10 Evidence for an In Vivo Photoprotective Effect of 1,25 Dihydroxyvitamin D3  KM Dixon¹, SS Deo¹, RGupta¹, M Slater¹, GM Halliday², VE Reeve³, RS Mason^{1  1}Department of Physiology and Institute for Biomedical Research, University of Sydney, NSW, Australia 2006. ²Department of Medicine (Dermatology) and ³Department of Veterinary Anatomy and Physiology, University of Sydney, NSW, 2006.

 

 

3.10-3.30  Effect of UVA on the skin immune system A. Fourtanier, E. Baron*, K. Cooper*, P. Krien, L. Meunier**, D. Moyal, S. Seite L'Oreal Corporate Research and Development, Paris. 

AFOURTANIER@recherche.loreal.com

 

3.30-4.00 Afternoon tea

 

4.00-5.30 Annual General Meeting

 

Conference Dinner. 7 pm at Three Five Seven. 357 King St. Newtown.

FRIDAY 28 NOVEMBER 2003

 

9.00-9.20. The Acute and Subchronic Effect of PCTH on Iron Excretion in Mice  Cynthia SM Wong and Des R Richardson  Iron Metabolism and Chelation Program, Children’s Cancer Institute Australia for Medical Research, PO Box 81, High Street, Randwick, Sydney, NSW, 2031, Australia  c.wong@ccia.org.au

 

9.20-9.40. Phototoxicity of Bithionol in Human Keratinocytes In Vitro: The Role of Oxidative Stress  L Reid¹ and RH Clothier^{2  1}Free Radical Biochemistry Laboratory, School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. ²F.R.A.M.E. Alternatives Laboratory, E Floor, Medical School, Queen’s Medical Centre, Nottingham, NG7 2UH, UK.  linzi.reid@canterbury.ac.nz.

 

9.40-10.00 Singlet Oxygen-Mediated Formation of Intracellular Peroxides on THP-1 Cells  Vanessa Policarpio, Clare L Hawkins and Michael J Davies  The Heart Research Institute, 145 Missenden Road, Camperdown, NSW, 2050, Australia  v.policarpio@hri.org.au

 

10.00-10.20. Synthetic isoflavones exhibit anti-inflammatory activity  Lam ANC, Walker C, Husband AJ  Faculty of Veterinary Science, University of Sydney, Sydney, NSW, Australia 2006  annalam@vetp.usyd.edu.au

 

10.20-10.40. The anti-inflammatory effects of frequency specific microcurrent treatment. Reilly W, Reeve V, Quinn C, McMakin C. wreilly@healthworld.com.au

 

10.40-11.10. Morning tea

 

11.10-11.30 Arsenic, a Model for Assessing Effects of Oxidative Strees on Gene Expression  ET Snow and KL McCluskey  Faculty of Science and Technology, Deakin University  esnow@deakin.edu.au

 

11.30-11.50. The Metastasis Suppressor Gene, NDRG1, is Markely Up-Regulated by Iron Chelators but not the DNA-Damaging Agent Actinomycin D  Nghia TV Le and Des R Richardson  Iron Metabolism and Chelation Program, Children’s Cancer Institute Australia for Medical Research, PO Box 81, High Street, Randwick, Sydney, NSW, 2031, Australia  n.le@ccia.org.au

 

11.50-12.10 Examination of the Pathophysiological Function of Frataxin Using Cells Transfected with an Anti-Sense Frataxin Expression Vector  Lijuan Xie, Ian A Napier and Des R Richardson  Iron Metabolism and Chelation Program, Children’s Cancer Institute Australia for Medical Research, PO Box 81, High Street, Randwick, Sydney, NSW, 2031.  lxie@ccia.org.au

 

12.10-12.30. Iron Chelators overcome N-MYC repression of NDRG1 in neuroblastoma cells.  Castelnoble LA, Le Nghia TV, Richardson, DR.  Iron Metabolism and Chelation Program, Children’s Cancer Institute Australia for Medical Research, PO Box 81, High Street, Randwick, Sydney, NSW, 2031, Australia  l.castelnoble@ccia.org.au

 

12.30-12.50. The Melanoma Tumour Antigen P97 (Melanotransferrin): Expression Studies and Splice Variants in Humans and Mice  LL Dunn, EO Sekyere and DR Richardson  Iron Metabolism and Chelation Program, Children’s Cancer Institute Australia for Medical Research, PO Box 81, High Street, Randwick, Sydney, NSW, 2031, Australia  ldunn@ccia.org.au

 

12.50-2.00 Lunch

 

2.00-2.20 Malignant Transformation of Solar Keratoses is Associated with Inflammation, Telomerase Reactivation and SW12/SNF2 Downregulation  AM Jones, LA MacDonald, NS Agar, A Nikolic, R Barnetson, GM Halliday  Dermatology research laboratories, Blackburn Building DO6, The University of Sydney, NSW 2006.  ajones@med.usyd.edu.au

 

 

2.20-2.40 The Photoprotective Effect of 1,25 Dihydroxyvitamin D₃, is Via the Rapid Response Pathway  K.M. Dixon¹, S.S. Deo¹, R. Gupta¹, G. Wong¹, J. Bishop², S. Ishizuka³, A.W. Norman², G.M. Halliday⁴, R.S. Mason^{1  1}Department of Physiology and Institute for Biomedical Research, University of Sydney, NSW, Australia, 2006, ²Department of Biochemistry, University of California, Riverside, CA, USA, 92521, ³Teijin Institute for Biomedical Research, Tokyo, Japan, 191-8512, ⁴Department of Medicine (Dermatology), University of Sydney, NSW, 2006.

 

 

2.40-3.00 Poster Session

 

3.00-3.20 Afternoon Tea

 

3.20-3.50. Human pigmentation and skin cancer: MC1R genotypes, phenotype and population genetics  Sturm, RA.  Institute for Molecular Bioscience, University of Queensland, Brisbane, Qld 4072  R.Sturm@imb.uq.edu.au

 

3.50-4.20 Sunlight and melanoma: behind complexity lies greater complexity  Whiteman, DC.   Population Studies and Human Genetics Division, Queensland Institute of Medical Research, PO Royal Brisbane Hospital. Queensland 4029.    daveW@qimr.edu.au

 

4.20-4.50. BRAF polymorphisms and risk of melanocytic neoplasia  Meyer P, Shi M, Roth R, Schmitt C, Kammerer S, Sergi C, Nelson M, Stapelmann H, Martin N, James M, Montgomery G, Haywood, N, Stark M, Braun A, Garbe C, Duffy D.  Queensland Institute of Medical Research, Herston, Queensland 4029  nickH@qimr.edu.au

 

4.50-5.00 Closing comments

 

POSTERS

 

Construction and Evaluation of an Escherichia coli uvrB::lux Biosensor for the Rapid Detection of DNA Damaging Agents

Simons K, Sbisa K, and Thomas SM

School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA, 5001

sue.thomas@flinders.edu.au

 

Cyclophosphamide Toxicity in Primary Mouse Hepatocytes

Ascher DB and Burcham PC

Molecular Toxicology Group, Clinical and Experimental Pharmacology, University of Adelaide, SA, 5005

david.ascher@adelaide.edu.au

 

Hydralazine, a Nucleophilic Protein Adduct-Trapping Drug, Blocks the Toxicity of Bifunctional Carbonyl Compounds

Kaminskas LM, Pyke SM and Burcham PC

 

Melanin Protects from Erythema Induced by Solar-Simulated or 310nm Ultraviolet Radiation, but not 290nm

Phan TA, Halliday GM, Barnetson RStC and Damian DL

Dermatology Department, Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, University of Sydney at Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, 2050, Australia

tai@med.usyd.edu.au

 

Singlet Oxygen-Mediated Formation of Histidine Peroxides Using Different Sensitizers

Policarpio V,¹, Bubb WA², Hawkins CL¹. and Davies MJ¹

¹The Heart Research Institute, 145 Missenden Road, Camperdown NSW 2050 Australia

²Department of Biochemistry, University of Sydney, NSW 2006, Australia

v.policarpio@hri.org.au

 

Effects of Arsenic on the Generation and Repair of Nuclear DNA Damage

Troy R. Durham and ET Snow. Faculty of Science and Technology, Deakin University. esnow@deakin.edu.au

 

Immune Protective Properties Of Bovine Colostrum Extracts Fed To Mice

Diane Titmuss, Christopher Quinn, *Wayne Reilly and Vivienne Reeve

Faculty of Veterinary Science, University of Sydney and *Health World Ltd., Qld.

Protection Against Immunosuppression And Carcinogenesis Induced With UV Radiation By The Flavone Luteolin.  E. Popova, C. Quinn, V. Reeve

Photobiology Research Group, Faculty of Veterinary Science, The University of Sydney, Sydney, NSW 2006

epop8401@mail.usyd.edu.au